HCID 21876061、化合物 → HCID 21876466、化合物

HRID 1454738ノート

反応式

HRID 1454738 の反応式
[C:1]([O:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[C:17]3[CH:18]=[C:19]([Cl:26])[C:20]([C:22]([F:25])([F:24])[F:23])=[CH:21][C:16]=3[N:15]=[C:14]2[C:27]([N:30]=[N+]=[N-])([CH3:29])[CH3:28])=[CH:9][CH:8]=1)(=[O:3])[CH3:2]>[Pd].CC([O-])=O.CC([O-])=O.[Pb+2].CO>[C:1]([O:4][CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([N:13]2[C:17]3[CH:18]=[C:19]([Cl:26])[C:20]([C:22]([F:24])([F:25])[F:23])=[CH:21][C:16]=3[N:15]=[C:14]2[C:27]([NH2:30])([CH3:29])[CH3:28])=[CH:11][CH:12]=1)(=[O:3])[CH3:2]

参加物

4

反応物 1

HCID 21876061HCID 21876061、化合物

生成物 1

HCID 21876466HCID 21876466、化合物収率 98.2%

試薬・触媒・溶媒 2

HCID 131709914Lindlars catalyst触媒HCID 887Methanol溶媒

実験手順

A mixture of 2-{4-[2-(1-azido-1-methylethyl)-6-chloro-5-(trifluoromethyl)-1H-benzimidazol-1-yl]phenyl}ethyl acetate (step 2, 133 mg, 0.28 mmol) and Lindlar catalyst (13 mg) in methanol (5 ml) was stirred under H2 atmosphere at room temperature for 2.5 h. The catalyst was removed by filtration through a pad of celite and the filtrates were concentrated to give the title compound as yellow oil (121 mg, 98%).

後処理

  1. customThe catalyst was removed by filtration through a pad of celite
  2. concentrationthe filtrates were concentrated

出典と根拠

ORDレコード
ord-0bb2e1845f1741ba84608e23359d856d
出典データセット
uspto-grants-2009_01
特許番号
US07479564B2

反応ノート

読み込み中…