3-(Trifluoromethyl)benzenesulfonyl chloride → N-(5-Methoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide

反応式

[CH3:1][O:2][CH2:3][C:4]1[CH:5]=[CH:6][C:7]([NH2:11])=[N:8][C:9]=1[CH3:10].[F:12][C:13]([F:25])([F:24])[C:14]1[CH:15]=[C:16]([S:20](Cl)(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1>>[CH3:1][O:2][CH2:3][C:4]1[CH:5]=[CH:6][C:7]([NH:11][S:20]([C:16]2[CH:17]=[CH:18][CH:19]=[C:14]([C:13]([F:12])([F:24])[F:25])[CH:15]=2)(=[O:22])=[O:21])=[N:8][C:9]=1[CH3:10]

参加物

反応物 2

HCID 27332503-(Trifluoromethyl)benzenesulfonyl chloride

HCID 688455515-(Methoxymethyl)-6-methylpyridin-2-amine

生成物 1

HCID 68846528N-(5-Methoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide

実験手順

This material was prepared in analogy to example 1 from 5-methoxymethyl-6-methyl-pyridin-2-ylamine (0.058 g) and 3-(trifluoromethyl)-benzenesulfonyl chloride (0.103 g) as a light yellow gum (0.1 g). MS (ESI−): 359.0 ([M−H]−)

出典と根拠

ORDレコード: ord-1408026a38d146c99ee86f0dc616e57b
出典データセット: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07482341B2

反応ノート

読み込み中…