3-Chloro-2-methylbenzenesulfonyl chloride → 3-Chloro-N-(5-methoxymethyl-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide

反応式

[CH3:1][O:2][CH2:3][C:4]1[CH:5]=[CH:6][C:7]([NH2:11])=[N:8][C:9]=1[CH3:10].[Cl:12][C:13]1[C:14]([CH3:23])=[C:15]([S:19](Cl)(=[O:21])=[O:20])[CH:16]=[CH:17][CH:18]=1>>[Cl:12][C:13]1[C:14]([CH3:23])=[C:15]([S:19]([NH:11][C:7]2[CH:6]=[CH:5][C:4]([CH2:3][O:2][CH3:1])=[C:9]([CH3:10])[N:8]=2)(=[O:21])=[O:20])[CH:16]=[CH:17][CH:18]=1

参加物

反応物 2

HCID 5227343-Chloro-2-methylbenzenesulfonyl chloride

HCID 688455515-(Methoxymethyl)-6-methylpyridin-2-amine

生成物 1

HCID 688407523-Chloro-N-(5-methoxymethyl-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide

実験手順

This material was prepared in analogy to example 1 from 5-methoxymethyl-6-methyl-pyridin-2-ylamine (0.058 g) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.094 g) as an off-white foam (0.093 g). MS (ESI−): 339.0 ([M−H]−)

出典と根拠

ORDレコード: ord-a0a8d60a3f6c4a0f8e44caa886326015
出典データセット: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07482341B2

反応ノート

読み込み中…