3-Chloro-2-methylbenzenesulfonyl chloride → 3-Chloro-N-[5-(4-fluoro-benzyloxymethyl)-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide
反応式
[F:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][O:7][CH2:8][C:9]2[CH:10]=[CH:11][C:12]([NH2:16])=[N:13][C:14]=2[CH3:15])=[CH:4][CH:3]=1.[Cl:19][C:20]1[C:21]([CH3:30])=[C:22]([S:26](Cl)(=[O:28])=[O:27])[CH:23]=[CH:24][CH:25]=1>>[Cl:19][C:20]1[C:21]([CH3:30])=[C:22]([S:26]([NH:16][C:12]2[CH:11]=[CH:10][C:9]([CH2:8][O:7][CH2:6][C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:18][CH:17]=3)=[C:14]([CH3:15])[N:13]=2)(=[O:28])=[O:27])[CH:23]=[CH:24][CH:25]=1参加物
3
実験手順
This material was prepared in analogy to example 1 from 5-(4-fluoro-benzyloxymethyl)-6-methyl-pyridin-2-ylamine (0.08 g) and 3-chloro-2-methyl-benzenesulfonyl chloride (0.08 g) as an amorphous light yellow solid (0.067 g). MS (ESI−): 433.1 ([M−H]−)
出典と根拠
- ORDレコード
- ord-c57e6423bf4244ada4cabea7bc1e093b
- 出典データセット
- uspto-grants-2009_01
- 特許番号
- US07482341B2
反応ノート
読み込み中…