Ammonium Hydroxide → 2-amino-5-(2,6-difluorophenyl)-6H-pyrido[1,2-b]pyridazin-6-one

HRID 1454971ノート

反応式

HRID 1454971 の反応式
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][C:10](=[O:20])[C:11]=2[C:12]2[C:17]([F:18])=[CH:16][CH:15]=[CH:14][C:13]=2[F:19])[N:7]=1.[NH4+:21].[Cl-].[NH4+].[OH-]>O>[NH2:21][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][C:10](=[O:20])[C:11]=2[C:12]2[C:17]([F:18])=[CH:16][CH:15]=[CH:14][C:13]=2[F:19])[N:7]=1

参加物

5

反応物 3

HCID 14923Ammonium HydroxideHCID 25517Ammonium ChlorideHCID 575312262-chloro-5-(2,6-difluorophenyl)-6H-pyrido[1,2-b]pyridazin-6-one

生成物 1

HCID 575312362-amino-5-(2,6-difluorophenyl)-6H-pyrido[1,2-b]pyridazin-6-one

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
90 °C

実験手順

To 2-chloro-5-(2,6-difluorophenyl)-6H-pyrido[1,2-b]pyridazin-6-one (1.1 g, 3.77 mmol) was added NH4Cl (100 mL) and NH4OH (100 mL). The resulting solution was heated to 90° C. and stirred for 16 hrs until complete. The reaction was cooled to ambient temperature and diluted with H2O (500 mL) until a precipitate formed. The solid precipitate was collected and dried to yield the title compound.

後処理

  1. temperatureThe reaction was cooled to ambient temperature
  2. customformed
  3. customThe solid precipitate was collected
  4. customdried

出典と根拠

ORDレコード
ord-08ee52dc7da84685874ac0be4d7a3057
出典データセット
uspto-grants-2009_01
特許番号
US07482345B2

反応ノート

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