1-(2,6-difluorophenyl)-7-[(2,4-difluorophenyl)ethynyl]-2H-quinolizin-2-one → HCID 68997044、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[C:10](=[O:29])[CH:11]=[CH:12][N:13]2[C:18]=1[CH:17]=[CH:16][C:15]([C:19]#[C:20][C:21]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=1[F:28])=[CH:14]2>CO.[Pd].CC([O-])=O.CC([O-])=O.[Pb+2]>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[C:10](=[O:29])[CH:11]=[CH:12][N:13]2[C:18]=1[CH:17]=[CH:16][C:15](/[CH:19]=[CH:20]\[C:21]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=1[F:28])=[CH:14]2参加物
4
実験手順
A solution of 1-(2,6-difluorophenyl)-7-[(2,4-difluorophenyl)ethynyl]-2H-quinolizin-2-one in methanol was added a catalytic amount of Lindlar catalyst under hydrogen atmosphere (1 atm) for 1 hour. The mixture was filtered through celite and the filtrate was concentrated. The crude material was purified by silica gel (100% ethyl acetate) to give the title compound.