Sulfuryl chloride → 2,4,6-Trichloropyrimidine-5-carbonyl chloride
反応式
[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([CH:9]=[O:10])=[C:4]([Cl:11])[N:3]=1.S(Cl)([Cl:15])(=O)=O>ClC(Cl)C>[Cl:1][C:2]1[N:3]=[C:4]([Cl:11])[C:5]([C:9]([Cl:15])=[O:10])=[C:6]([Cl:8])[N:7]=1参加物
4
反応条件
- 温度
- 60 °C
実験手順
To the subtitle product of step i) (5.0 g) in dichloroethane (25 ml) was added aza-bis-isobutyronitrile (25 mg) and the mixture heated to 60° C. Sulfuryl chloride (3.67 g) was then added and the reaction heated at 75° C. for 4 h. The same amount of aza-bis-isobutyronitrile (4×25 mg) and sulfuryl chloride (4×3.36 g) was added for 4 days on each day interval. The solvent was evaporated to give a yellow oil which was distilled under reduced pressure to yield the subtitle compound as a yellow oil. Yield 5.8 g.
後処理
- temperaturethe reaction heated at 75° C. for 4 h
- customThe solvent was evaporated
- customto give a yellow oil which
- distillationwas distilled under reduced pressure
出典と根拠
- ORDレコード
- ord-052ad9492a7e473c9c7e75c239f8f2fb
- 出典データセット
- uspto-grants-2009_01
- 特許番号
- US07482355B2
反応ノート
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