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p-Toluenesulfonate → 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluenesulfonate | HCID 85570 | — |
| 反応物 | (-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid | HCID 2733226 | — |
| 反応物 | N-[1(S)-Ethoxycarbonyl-3-phenylpropyl]-L-alanine | HCID 5702571 | — |
| 生成物 | 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid | HCID 95489 | — |
反応手順
The first step of Method-I consists of condensation of N-[1(S)-carboethoxy-3-phenylpropyl]-(S)-alanine (III) with the para-toluene sulfonate salt of the benzyl ester of (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid (IV) to give the benzyl ester of (S, S, S)-2-{2-{(1-ethoxycarbonyl)-3-phenylpropyl)amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid or quinapril benzyl ester which is isolated as the maleic acid salt (V).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07482361B2 |
| 出典データセット | uspto-grants-2009_01 |
| ORD ID | ord-ab98451813ec47e8a626bbdb71ae2dfa |
| 出典メモ | uspto-grants-2009_01 |