Hydrogen Peroxide → 2-tert-Butyl-1-oxo-1lambda~5~-pyridinato

HRID 1455342ノート

反応式

HRID 1455342 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH:11]O>CC(O)=O.C(Cl)Cl>[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N+:6]=1[O-:11])([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 2

HCID 784Hydrogen PeroxideHCID 1386302-tert-Butylpyridine

生成物 1

HCID 187150642-tert-Butyl-1-oxo-1lambda~5~-pyridinato収率 71.5%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 6344Dichloromethane溶媒

実験手順

Preparation C3, Step 1: 2-tert-butylpyridine (2.00 g, 14.8 mmol, 1 eq.) was dissolved in HOAc (10 mL) and 30% hydrogen peroxide (1.68 mL, 14.8 mmol, 1 eq.) at room temperature then the reaction was refluxed for 20 hours. The reaction was stripped to obtain an amber oil which was dissolved in methylene chloride (10 mL) then dried over sodium sulfate and stripped to obtain 2-tert-butylpyridine-N-oxide (1.60 g) as an amber oil. Yield=71.5%. LCMS detects (M+H)+=152.09.

後処理

  1. customto obtain an amber oil which
  2. dry with materialthen dried over sodium sulfate

出典と根拠

ORDレコード
ord-e2b770de86f04b09beee93a9f9b05bbc
出典データセット
uspto-grants-2009_01
特許番号
US07482335B2

反応ノート

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