Ethyl 8-chloro-1-cyclopropyl-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate → 1-Cyclopropyl-1,4-dihydro-7-fluoro-8-chloro-4-oxo-quinoline-3-carboxylic Acid

HRID 1455497ノート

反応式

HRID 1455497 の反応式
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[C:10]([Cl:18])[C:11]([F:17])=[CH:12][CH:13]=2)[N:8]([CH:19]2[CH2:21][CH2:20]2)[CH:7]=1)=[O:5])C>C(O)(=O)C.O.S(=O)(=O)(O)O>[CH:19]1([N:8]2[C:9]3[C:14](=[CH:13][CH:12]=[C:11]([F:17])[C:10]=3[Cl:18])[C:15](=[O:16])[C:6]([C:4]([OH:5])=[O:3])=[CH:7]2)[CH2:20][CH2:21]1

参加物

5

反応物 1

HCID 18333191Ethyl 8-chloro-1-cyclopropyl-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

生成物 1

HCID 183332011-Cyclopropyl-1,4-dihydro-7-fluoro-8-chloro-4-oxo-quinoline-3-carboxylic Acid

試薬・触媒・溶媒 3

HCID 176Acetic Acid溶媒HCID 962Water溶媒HCID 1118Sulfuric Acid溶媒

実験手順

A quantity of 1.93 g of ethyl-1-cyclopropyl-1,4-dihydro-7-fluoro-8-chloro-4-oxo-quinoline-3-carboxylate is dissolved in 30 ml of a mixture of acetic acid, water and sulfuric acid (8/6/1). the mixture is refluxed for 3 hours and cooled to room temperature. The desired compound is collected by filtration and air dried.

後処理

  1. temperaturethe mixture is refluxed for 3 hours
  2. filtrationThe desired compound is collected by filtration and air
  3. customdried

出典と根拠

ORDレコード
ord-7b96b7240d144e6090db6f6e1672a75f
出典データセット
uspto-grants-2009_01
特許番号
US07482454B2

反応ノート

読み込み中…