Methanol → 3-(3-Bromo-4-methoxyphenyl)propanoic acid

HRID 1455709

反応式

HRID 1455709 の反応式
C([O:3][C:4](=[O:16])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[C:9]([Br:15])[CH:8]=1)C.[OH-].[K+].CO>O>[Br:15][C:9]1[CH:8]=[C:7]([CH2:6][CH2:5][C:4]([OH:16])=[O:3])[CH:12]=[CH:11][C:10]=1[O:13][CH3:14]

参加物

5

反応物 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 69049487Ethyl 3-(3-bromo-4-methoxyphenyl)propanoate

生成物 1

HCID 45476083-(3-Bromo-4-methoxyphenyl)propanoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

154 g (0.535 mol) of ethyl3-(3-bromo-4-methoxyphenyl)propanoate are mixed with 45 g (0.8 mol) of potassium hydroxide, 600 ml of methanol and 300 ml of water. The mixture is heated at reflux for 3 hours, and the methanol is then evaporated off. The solution obtained is washed with ether; the aqueous phase is acidified and extracted with ether. The organic phase is dried (Na2SO4), and the solvents are evaporated off: white solid (132.7 g; 96%).

後処理

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 3 hours
  3. customthe methanol is then evaporated off
  4. customThe solution obtained
  5. washis washed with ether
  6. extractionextracted with ether
  7. dry with materialThe organic phase is dried (Na2SO4)
  8. customthe solvents are evaporated off

出典と根拠

ORDレコード
ord-9249e0c98ee743babcb237339e0146da
出典データセット
uspto-grants-2009_01
特許番号
US07482484B2

関連ノート

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