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Formaldehyde → 4-(N,N-dimethylaminomethyl) benzoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | Methyl 4-(aminomethyl)benzoate | HCID 571728 | — |
| 反応物 | 4-[(Dimethylamino)methyl]benzoic acid | HCID 826319 | — |
| 生成物 | 4-(N,N-dimethylaminomethyl) benzoyl chloride | HCID 13748965 | — |
反応手順
The 4-(N,N-dimethylaminomethyl) benzoyl chloride was prepared by reacting the acid with excess oxalyl chloride for 1 hr at 25° C. The 4-(N,N-dimethylaminomethyl) benzoic acid was in turn prepared from methyl 4-aminomethylbenzoate via reductive alkylation (CH2O, Na(OAc)3 BH as in J. Org. Chem., 1972, 37, 1673) followed by hydrolysis using 10% aqueous NaOH.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05843905 |
| 出典データセット | uspto-grants-1998_12 |
| ORD ID | ord-d77ffea2c0ff485a9d1599781addece9 |
| 出典メモ | uspto-grants-1998_12 |