Ammonia → 6-Chloropyridazine-3-carboxamide
反応式
[NH3:1].[Cl:2][C:3]1[N:8]=[N:7][C:6]([C:9]([O:11]CCCC)=O)=[CH:5][CH:4]=1>CO>[Cl:2][C:3]1[N:8]=[N:7][C:6]([C:9]([NH2:1])=[O:11])=[CH:5][CH:4]=1参加物
4
実験手順
Excess gaseous ammonia was added to an ice bath cooled solution of n-butyl 6-chloropyridazine-3-carboxylate (40 g) in methanol (280 ml). The mixture was stirred at ambient temperature for 4 hours and the resulting residue filtered off, washed with methanol (20 ml) and dried to give 6-chloropyridazine-3-carboxamide (28.05 g, 95.5% yield), mpt. 243°-5° C.
後処理
- filtrationthe resulting residue filtered off
- washwashed with methanol (20 ml)
- customdried
出典と根拠
- ORDレコード
- ord-0006ddc8fcd140b3801590f75f668e11
- 出典データセット
- uspto-grants-1998_12
- 特許番号
- US05843942
反応ノート
読み込み中…