Carbon tetrabromide → 5-Bromo-2-(2-thienylmethoxy)benzyl bromide

HRID 1455968ノート

反応式

HRID 1455968 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:11][C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)=[C:6]([CH:9]=1)[CH2:7]O.C(Br)(Br)(Br)[Br:18].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>ClCCl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:11][C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)=[C:6]([CH:9]=1)[CH2:7][Br:18]

参加物

5

反応物 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 289814405-Bromo-2-(2-thienylmethoxy)benzenemethanol

生成物 1

HCID 221055055-Bromo-2-(2-thienylmethoxy)benzyl bromide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 5-bromo-2-(2-thienylmethoxy)benzyl alcohol (0.53 g, 1.77 mmoles) in dichloromethane (12 ml) was cooled in an ice bath and treated with carbon tetrabromide (0.73 g, 2.2 mmol) polymer bound triphenylphosphine (0.65 g, 1.95 mmol) and stirred at ambient temperature for 42 hours. The reaction was filtered and evaporated. Chromatography (eluant: ethyl acetate/hexane) gave 5-bromo-2-(2-thienylmethoxy)benzyl bromide as a white solid (0.29, 45%).

後処理

  1. filtrationThe reaction was filtered
  2. customevaporated

出典と根拠

ORDレコード
ord-994f6e71f46847b498bd0647c996af81
出典データセット
uspto-grants-1998_12
特許番号
US05843942

反応ノート

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