Methyl 3-oxoheptanoate → HCID 178441198、化合物

HRID 1455997ノート

反応式

HRID 1455997 の反応式
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.O=[C:8]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:9][C:10](OC)=[O:11]>C1(C)C=CC=CC=1>[CH2:14]([C:8]1[CH:9]=[C:10]([OH:11])[N:3]2[N:4]=[CH:5][CH:6]=[C:2]2[N:1]=1)[CH2:15][CH2:16][CH3:17]

参加物

4

反応物 2

HCID 546075Methyl 3-oxoheptanoateHCID 178418806HCID 178418806、化合物

生成物 1

HCID 178441198HCID 178441198、化合物収率 80.1%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
100 °C

実験手順

A suspension of 100 g of 3-aminopyrazole and 190 g of methyl 3-oxoheptanoate in 120 ml of toluene was heated under reflux at 100° C. for 3 hours and cooled. Toluene was distilled off under reduced pressure, and diethyl ether was added to the residue. The crystals precipitated were collected and sequentially washed with diethyl ether and acetonitrile to provide 184 g of 5-n-butyl-7-hydroxypyrazolo[1,5-a]pyrimidine as colorless crystals. The structure and melting point of the compound obtained are shown in Table 1 below.

後処理

  1. temperaturewas heated
  2. temperaturecooled
  3. distillationToluene was distilled off under reduced pressure, and diethyl ether
  4. additionwas added to the residue
  5. customThe crystals precipitated
  6. customwere collected
  7. washsequentially washed with diethyl ether and acetonitrile

出典と根拠

ORDレコード
ord-752420e2becf4e538d295bc827adb042
出典データセット
uspto-grants-1998_12
特許番号
US05843951

反応ノート

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