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4,6-Dichloropyrimidine → 4-Chloro-6-(3,5-dimethylpiperidin-1-yl)pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4,6-Dichloropyrimidine | HCID 70943 | — |
| 反応物 | 3,5-Dimethylpiperidine | HCID 118259 | — |
| 生成物 | 4-Chloro-6-(3,5-dimethylpiperidin-1-yl)pyrimidine | HCID 59341126 | 66% |
反応手順
0.3 g of 4,6-dichloropyrimidine and 0.34 g of 3,5-dimethylpiperidine (cis/trans diastereomer=about 3/1) were mixed and left for 5 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.3 g of 4-chloro-6-(3,5-dimethylpiperidino)pyrimidine. This compound had the cis/trans diastereomer originated two methyls on the pyperidine ring. The ratio of the cis/trans diastereomer was about 3.1/1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732448B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-d6b2761139a1439abcd16946d8b3148b |
| 出典メモ | uspto-grants-2010_06 |