2-Chloro-4-fluoro-6-nitrophenol → 2-Chloro-4-fluoro-6-aminophenol Hydrochloride

HRID 1456655ノート

反応式

HRID 1456655 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([N+:9]([O-])=O)[C:3]=1[OH:12].[H][H]>CCO.[Pt]=O>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([NH2:9])[C:3]=1[OH:12]

参加物

5

反応物 2

HCID 37278862-Chloro-4-fluoro-6-nitrophenolHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 221171192-Chloro-4-fluoro-6-aminophenol Hydrochloride収率 141.6%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒

実験手順

A mixture of compound 711 (23.4 g, 0.122 mol) and platinum oxide (2.3 g) in absolute EtOH (120 mL) was placed under 1 atm of hydrogen and stirred until complete reduction had occurred. The hydrogen was replaced with nitrogen and the reaction was filtered through Celite. The filtrate was diluted with Et2O (300 mL) and gaseous hydrochloric acid was bubbled through the solution to provide a white precipitate. The solid was collected and dried under vacuum to provide 17.1 g of compound 712 as a white solid. ##STR91##

後処理

  1. filtrationthe reaction was filtered through Celite
  2. additionThe filtrate was diluted with Et2O (300 mL) and gaseous hydrochloric acid
  3. customwas bubbled through the solution
  4. customto provide a white precipitate
  5. customThe solid was collected
  6. customdried under vacuum

出典と根拠

ORDレコード
ord-2dcc895c2f8f4a83b59979bb34231267
出典データセット
uspto-grants-1998_12
特許番号
US05843904

反応ノート

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