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3,5-Dimethylpiperidine → 4-Chloro-6-(cis-3,5-dimethylpiperidino)-5-fluoropyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,5-Dimethylpiperidine | HCID 118259 | — |
| 反応物 | 4,6-Dichloro-5-fluoropyrimidine | HCID 11286675 | — |
| 生成物 | 4-Chloro-6-(cis-3,5-dimethylpiperidino)-5-fluoropyrimidine | HCID 86607460 | — |
| 生成物 | 4-Chloro-6-(trans-3,5-dimethylpiperidino)pyrimidin | HCID 86607469 | — |
反応手順
0.2 g of 4,6-dichloro-5-fluoropyrimidine and 0.41 g of 3,5-dimethylpiperidine (cis/trans diastereomer=about 3/1) were mixed and left for 30 minutes at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.1 g of 4-chloro-6-(cis-3,5-dimethyl piperidino)-5-fluoropyrimidine and 0.05 g of 4-chloro-6-(trans-3,5-dimethylpiperidino)pyrimidin.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732448B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-f86402b91a3147cea90054d8288cee9e |
| 出典メモ | uspto-grants-2010_06 |