Methyl 4-chloro-3-nitrobenzoate → Methyl 4-methoxy-3-nitrobenzoate
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13]=1Cl)[C:7]([O:9][CH3:10])=[O:8])([O-:3])=[O:2].[CH3:15][O-:16].[Na+]>CO>[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13]=1[O:16][CH3:15])[C:7]([O:9][CH3:10])=[O:8])([O-:3])=[O:2]参加物
4
実験手順
Methyl 3-nitro-4-chlorobenzoate (COMPOUND XIII) (see above for synthesis of 4-chloro-anti-CG) (1 equivalent) is treated with sodium methoxide (1.1 equivalent) in methanol with heating to produce the methyl 3-nitro-4-methoxybenzoate (COMPOUND XIV) which is purified by column chromatography and/or crystallization.
後処理
- temperaturewith heating
出典と根拠
- ORDレコード
- ord-338e1f8ba593439d9dc45880a5dff4b4
- 出典データセット
- uspto-grants-1998_12
- 特許番号
- US05844110
反応ノート
読み込み中…