6-Chloroindole → 6-Chloro-3-(1,2,3,6-tetrahydro-1,3-dimethyl-4-pyridinyl)-1H-indole

反応式

[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[CH3:11][N:12]1[CH2:17][CH2:16][C:15](=O)[CH:14]([CH3:19])[CH2:13]1>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:15]3[CH:14]([CH3:19])[CH2:13][N:12]([CH3:11])[CH2:17][CH:16]=3)=[CH:7][NH:8]2)=[CH:4][CH:3]=1

参加物

反応物 2

HCID 871116-Chloroindole

HCID 1073111,3-Dimethyl-4-piperidone

生成物 1

HCID 187972006-Chloro-3-(1,2,3,6-tetrahydro-1,3-dimethyl-4-pyridinyl)-1H-indole収率 63%

実験手順

Beginning with 0.97 gm (6.4 mMol) 6-chloro-1H-indole and 1.6 gm (13.0 mMol) 1,3-dimethyl-4-piperidone, 1.05 gm (63%) of the title compound were recovered as a crystalline solid.

出典と根拠

ORDレコード: ord-df33bd14cceb4a7dadd362cd8f031cf7
出典データセット: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05846982

反応ノート

読み込み中…