5-Bromoindole → 5-Bromo-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

反応式

[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.Cl.O.[NH:13]1[CH2:18][CH2:17][C:16](=O)[CH2:15][CH2:14]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:16]1[CH2:17][CH2:18][NH:13][CH2:14][CH:15]=1

参加物

反応物 2

HCID 249055-Bromoindole

HCID 2723901Piperonylamine

生成物 1

HCID 27637245-Bromo-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole収率 93.5%

実験手順

Beginning with 6.2 gm (31.6 mMol) 5-bromo-1H-indole and 4.7 gm (30.6 mMol) 4-piperidone monohydrate hydrochloride, 7.93 gm (93%) of the title compound were recovered as a solid.

出典と根拠

ORDレコード: ord-9d133a30107e47d184991b50b0301833
出典データセット: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05846982

反応ノート

読み込み中…