Ethanol → 5-(4,5-dihydrothiazol-5-yl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

HRID 1457021ノート

反応式

HRID 1457021 の反応式
C([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[C:12]1[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH:17]=1)#N.[SH:19][CH2:20][CH2:21][NH2:22].[CH2:23](O)C>>[S:19]1[CH:20]([C:3]2[CH:4]=[C:5]3[C:9](=[CH:10][CH:11]=2)[NH:8][CH:7]=[C:6]3[C:12]2[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH:17]=2)[CH2:21][N:22]=[CH:23]1

参加物

4

反応物 3

HCID 702EthanolHCID 6058CysteamineHCID 149732163-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-5-carbonitrile

生成物 1

HCID 187971695-(4,5-dihydrothiazol-5-yl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole収率 51%

実験手順

A mixture of 1.0 gm (4.2 mMol) 5-cyano-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole and 0.90 gm (11.7 mMol) 2-mercaptoethylamine in 20 mL ethanol was heated to reflux for 18 hours. The reaction mixture was cooled to room temperature and a colorless crystalline solid formed. The solid was isolated by filtration, washed with ethanol and dried under reduced pressure to provide 0.64 gm (51%) of the title compound.

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 18 hours
  3. customa colorless crystalline solid formed
  4. customThe solid was isolated by filtration
  5. washwashed with ethanol
  6. customdried under reduced pressure

出典と根拠

ORDレコード
ord-331219b6c5d34dbc926527c42b534218
出典データセット
uspto-grants-1998_12
特許番号
US05846982

反応ノート

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