1,1-Dimethylethyl 3,3-dimethyl-2-oxo-1-piperidinecarboxylate → 3,3-Dimethylpiperidin-2-one

HRID 1457220ノート

反応式

HRID 1457220 の反応式
[CH3:1][C:2]1([CH3:16])[CH2:7][CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[C:3]1=[O:15]>CO.Cl.CCOCC>[CH3:1][C:2]1([CH3:16])[CH2:7][CH2:6][CH2:5][NH:4][C:3]1=[O:15]

参加物

5

反応物 1

HCID 572676081,1-Dimethylethyl 3,3-dimethyl-2-oxo-1-piperidinecarboxylate

生成物 1

HCID 112404853,3-Dimethylpiperidin-2-one

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

The title compound of Step (B) (440 mg, 1.94 mmol) in 4 ml MeOH and 15 ml 1N HCl in Et2O was stirred at room temperature overnight. The solvent was evaporated and dried in vacuo to provide the title compound of this step as a light yellow solid which was relatively pure and was used in the next step without further purification.

後処理

  1. customThe solvent was evaporated
  2. customdried in vacuo

出典と根拠

ORDレコード
ord-c0761b5ec2644a81975de9f8880552eb
出典データセット
uspto-grants-1998_12
特許番号
US05846990

反応ノート

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