Methylamine → (2S,3R)-3-(4-methylphenyl)-2,3-epoxy-N-methylpropionamide

HRID 1457259ノート

反応式

HRID 1457259 の反応式
C[O:2][C:3](=O)[C@H:4]1[O:6][C@@H:5]1[C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=1.[CH3:15][NH2:16]>CO>[CH3:13][C:10]1[CH:11]=[CH:12][C:7]([C@H:5]2[O:6][C@@H:4]2[C:3]([NH:16][CH3:15])=[O:2])=[CH:8][CH:9]=1

参加物

4

反応物 2

HCID 6329MethylamineHCID 10176494(2S,3R)-3-(4-methylphenyl)-2,3-epoxypropionic acid methyl ester

生成物 1

HCID 56977863(2S,3R)-3-(4-methylphenyl)-2,3-epoxy-N-methylpropionamide収率 91.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To a mixture of (2S,3R)-3-(4-methylphenyl)-2,3-epoxypropionic acid methyl ester (1.92 g) and methanol (10 ml) is added dropwise a solution of 40% aqueous methylamine solution (2.37 g) in methanol (10 ml) under ice-cooling. The reaction mixture is stirred under ice-cooling for one hour, and concentrated under reduced pressure. To the residue is added ether, and the precipitated crystals are collected by filtration, washed, and dried at 50° C. to give (2S,3R)-3-(4-methylphenyl)-2,3-epoxy-N-methylpropionamide (1.75 g).

後処理

  1. temperaturecooling
  2. temperaturecooling for one hour
  3. concentrationconcentrated under reduced pressure
  4. additionTo the residue is added ether
  5. filtrationthe precipitated crystals are collected by filtration
  6. washwashed
  7. customdried at 50° C.

出典と根拠

ORDレコード
ord-9db6e93a58d04a99a57f88bbadf95848
出典データセット
uspto-grants-1998_12
特許番号
US05847122

反応ノート

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