Water → HCID 23289956、化合物

HRID 1457525ノート

反応式

HRID 1457525 の反応式
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:8][C:9]([C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][C:15](=[O:20])[CH2:14]2)=[O:10].O>CN(C)C=O>[N:1]1([CH2:8][C:9]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14]3)=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 962WaterHCID 8082PiperidineHCID 220993095-(Bromoacetyl)-1,3-dihydro-2H-indol-2-one

生成物 1

HCID 23289956HCID 23289956、化合物収率 49.1%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of piperidine (0.39 ml, 3.9 mmole) and 5-(2-bromoacetyl)-2-indolinone (500 mg, 1.97 mmole) in N,N-dimethylformamide (15 ml) was stirred at room temperature 4 h then was poured into water (50 ml) and washed with dichloromethane (250 ml), the organic solution was washed with water several times and dried over sodium sulfate. After evaporation of the solvent the residue was chromatographed on siiica-gel using ethyl acetate as eluant to give 5-(2-piperidin-1-yl-acetyl)-2-indolinone (250 mg).

後処理

  1. washwashed with dichloromethane (250 ml)
  2. washthe organic solution was washed with water several times
  3. dry with materialdried over sodium sulfate
  4. customAfter evaporation of the solvent the residue
  5. customwas chromatographed on siiica-gel

出典と根拠

ORDレコード
ord-2ec7ae9f58e54e2bb562f0ff5e9b9647
出典データセット
uspto-grants-1998_12
特許番号
US05849710

反応ノート

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