Toluene → 1,2-Bis(4-methoxyphenylmethyl)-4-nitropyrazolidine

反応式

C1(C)C=CC=CC=1.Cl.Cl.[CH3:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][NH:19][NH:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=2)=[CH:14][CH:13]=1.O1CCN([CH2:36][CH:37]([N+:45]([O-:47])=[O:46])[CH2:38]N2CCOCC2)CC1>CO>[CH3:29][O:28][C:25]1[CH:24]=[CH:23][C:22]([CH2:21][N:20]2[CH2:38][CH:37]([N+:45]([O-:47])=[O:46])[CH2:36][N:19]2[CH2:18][C:15]2[CH:14]=[CH:13][C:12]([O:11][CH3:10])=[CH:17][CH:16]=2)=[CH:27][CH:26]=1

参加物

実験手順

To a mixed solution of toluene (8 ml) and methanol (12 ml) were added 1,2-bis(4- methoxyphenylmethyl)hydrazine dihydrochloride (0.99 g) and 1,3- dimorpholino-2-nitropropane (0.75 g). The mixture was refluxed with heating for 3 hours. The reaction solution was concentrated under a vacuum, purified by silica gel column chromatography (n-hexane:ethyl acetate=3:1), thereby yielding 0.88 g (86%) of 1,2-bis (4-methoxyphenylmethyl)-4-nitropyrazolidine.