Potassium sodium tartarate → 4-Amino-1,2-bis(4-methoxyphenylmethyl)pyrazolidine

反応式

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][N:10]2[CH2:14][CH:13]([N+:15]([O-])=O)[CH2:12][N:11]2[CH2:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=2)=[CH:5][CH:4]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].C(C(C(C([O-])=O)O)O)([O-])=O.[K+].[Na+]>>[NH2:15][CH:13]1[CH2:12][N:11]([CH2:18][C:19]2[CH:20]=[CH:21][C:22]([O:25][CH3:26])=[CH:23][CH:24]=2)[N:10]([CH2:9][C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[CH2:14]1

参加物

反応物 3

HCID 9855836Potassium sodium tartarate

HCID 130762701,2-Bis(4-methoxyphenylmethyl)-4-nitropyrazolidine

HCID 21226445Aluminium lithium hydride

生成物 1

HCID 221019084-Amino-1,2-bis(4-methoxyphenylmethyl)pyrazolidine収率 99.2%

実験手順

To a solution of 1,2-bis(4-methoxyphenylmethyl)-4-nitropyrazolidine (0.88 g) in diethylether anhydride (20 ml) was gradually added lithium aluminum hydride (0.38 g) while being cooled with ice. After being refluxed with heating for two hours, the reaction liquid, with an aqueous sodium potassium tartrate solution added thereto, was extracted with ether. The extract was concentrated under a vacuum, thereby yielding 0.80 g of a raw product of the aimed compound.