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4,6-Dichloropyrimidine → 4-Chloro-6-(cis-2,6-dimethylpiperidino)pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4,6-Dichloropyrimidine | HCID 70943 | — |
| 反応物 | rel-(2R,6S)-2,6-Dimethylpiperidine | HCID 641768 | — |
| 生成物 | 4-Chloro-6-(cis-2,6-dimethylpiperidino)pyrimidine | HCID 86607466 | 27.7% |
反応手順
0.5 g of 4,6-dichloropyrimidine and 0.76 g of cis-2,6-dimethylpiperidine were mixed and stirred for 10 hours at 90%. The reaction mixture was subjected to silica gel column chromatography to obtain 0.21 g of 4-chloro-6-(cis-2,6-dimethylpiperidino)pyrimidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732448B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-f5e9b66fe77449749982e038ebebf7e4 |
| 出典メモ | uspto-grants-2010_06 |