N-(3-Fluoro-4-methyl-5-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide → N-(3-Fluoro-4-methyl-5,6,7,8-tetrahydro-1-naphthyl)acetamide

HRID 1458310ノート

反応式

HRID 1458310 の反応式
[C:1]([NH:4][C:5]1[CH:14]=[C:13]([F:15])[C:12]([CH3:16])=[C:11]2[C:6]=1[CH2:7][CH2:8][CH2:9][C:10]2=O)(=[O:3])[CH3:2].[H][H]>[C].[Pd].CO>[C:1]([NH:4][C:5]1[CH:14]=[C:13]([F:15])[C:12]([CH3:16])=[C:11]2[C:6]=1[CH2:7][CH2:8][CH2:9][CH2:10]2)(=[O:3])[CH3:2]

参加物

5

反応物 2

HCID 22101954N-(3-Fluoro-4-methyl-5-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 10799012N-(3-Fluoro-4-methyl-5,6,7,8-tetrahydro-1-naphthyl)acetamide収率 80.8%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

反応条件

温度
50 °C

実験手順

In a 50-ml autoclave, 1.0 g of 5-acetylamino-7 -fluoro-8-methyl-l-tetralone and 10 ml of methanol were charged. To the resulting mixture, 0.5 g of 10% palladium-carbon was added. The hydrogen pressure was increased to 40 kg/cm2 at room temperature, under which the resulting mixture was stirred at 50° C. for 18 hours. After the completion of the reaction, the reaction mixture was filtered. The catalyst so obtained was washed with chloroform and then the filtrate was concentrated under reduced pressure. To the residue, isopropyl ether was added. The crystals so precipitated were collected by filtration, followed by drying under reduced pressure, whereby 0.76 g of the title compound was obtained.

後処理

  1. customAfter the completion of the reaction
  2. filtrationthe reaction mixture was filtered
  3. customThe catalyst so obtained
  4. washwas washed with chloroform
  5. concentrationthe filtrate was concentrated under reduced pressure
  6. additionTo the residue, isopropyl ether was added
  7. customThe crystals so precipitated
  8. filtrationwere collected by filtration
  9. customby drying under reduced pressure

出典と根拠

ORDレコード
ord-25d2f2f9781a4804bd7db89a0ea1fa19
出典データセット
uspto-grants-1998_12
特許番号
US05849945

反応ノート

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