関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | rel-(2R,6S)-2,6-Dimethylpiperidine | HCID 641768 | — |
| 反応物 | 4,6-Dichloro-5-fluoropyrimidine | HCID 11286675 | — |
| 生成物 | 4-Chloro-6-(cis-2,6-dimethylpiperidino)-5-fluoropyrimidine | HCID 86607467 | 57.5% |
反応手順
0.25 g of 4,6-dichloro-5-fluoropyrimidine and 0.34 g of cis-2,6-dimethylpiperidine were mixed and stirred for 11 hours at 70° C. The reaction mixture was subjected to silica gel column chromatography to obtain 0.21 g of 4-chloro-6-(cis-2,6-dimethylpiperidino)-5-fluoropyrimidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07732448B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-0817df69e5fb453f85648bdb00310dde |
|---|
| 出典メモ | uspto-grants-2010_06 |
|---|
