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Piperidine → 1-(Quinoxalin-6-ylcarbonyl)piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | Quinoxaline-6-carboxylic acid | HCID 674813 | — |
| 反応物 | Bis-(1H-imidazol-2-YL)-methanone | HCID 5250894 | — |
| 反応物 | 1-(Quinoxalin-6-ylcarbonyl)-1,2,3,6-tetrahydropyridine | HCID 11630079 | — |
| 生成物 | 1-(Quinoxalin-6-ylcarbonyl)piperidine | HCID 148184 | — |
反応手順
The coupling of 6-quinoxalinecarboxylic acid to piperidine is accomplished in a manner similar to that used for the preparation of Invention Compound XIII, or by any other method known in the art for activation of aromatic carboxylic acids, such as, for example, activation by carbonyl diimidazole. 1H NMR δ 1.56 and 1.73 (br, 6), 3.40 (br s, 2), 3.79 (br s, 2), 7.82 (dd, 1, J=8.8, 1.9 Hz), 8.13 (d, 1, J=1.6 Hz), 8.17 (d, 1, 8.6 Hz), and 8.9 ppm (m, 2).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05852008 |
| 出典データセット | uspto-grants-1998_12 |
| ORD ID | ord-07b37a91766e4329953fb8f1ee583032 |
| 出典メモ | uspto-grants-1998_12 |