Hydrochloric Acid → HCID 22097041、化合物
反応式
N[C:2]1[C:3]([O:24]C)=[N:4][C:5]2[C:10]([N:11]=1)=[C:9]([N:12]([CH2:17][CH3:18])[S:13]([CH3:16])(=[O:15])=[O:14])[C:8]([Cl:19])=[C:7]([C:20]([F:23])([F:22])[F:21])[CH:6]=2.Cl.[O:27]1CCOCC1>>[Cl:19][C:8]1[C:9]([N:12]([CH2:17][CH3:18])[S:13]([CH3:16])(=[O:15])=[O:14])=[C:10]2[C:5](=[CH:6][C:7]=1[C:20]([F:21])([F:22])[F:23])[NH:4][C:3](=[O:24])[C:2](=[O:27])[NH:11]2参加物
4
実験手順
A mixture of N-(3-amino-6-chloro-7-trifluoromethyl-2-methoxyquinoxalin-5-yl)-N-ethyl-methanesulphonamide (step (a) above, 70 mg, 0.18 mmol), 2M hydrochloric acid (3 ml) and dioxane (6 ml) was heated at reflux for 2 h, cooled and concentrated under reduced pressure. The residue was suspended in water, filtered and the solid was washed with water. After being dried, the title compound (33 mg, 48%) was obtained as a white solid, m.p. >300° C.
後処理
- temperaturewas heated
- temperature