Methyl Isocyanate → N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)-N-(2-[methylaminocarbonyl]aminoethyl) methanesulphonamide

HRID 1458560ノート

反応式

HRID 1458560 の反応式
[CH3:1][N:2]=[C:3]=[O:4].[Cl:5][C:6]1[C:7]([N:21]([CH2:26][CH2:27][NH2:28])[S:22]([CH3:25])(=[O:24])=[O:23])=[C:8]2[C:13](=[CH:14][C:15]=1[Cl:16])[N:12]=[C:11]([O:17][CH3:18])[C:10]([O:19][CH3:20])=[N:9]2>ClCCl>[Cl:5][C:6]1[C:7]([N:21]([CH2:26][CH2:27][NH:28][C:3]([NH:2][CH3:1])=[O:4])[S:22]([CH3:25])(=[O:24])=[O:23])=[C:8]2[C:13](=[CH:14][C:15]=1[Cl:16])[N:12]=[C:11]([O:17][CH3:18])[C:10]([O:19][CH3:20])=[N:9]2

参加物

4

反応物 2

HCID 12228Methyl IsocyanateHCID 54554464HCID 54554464、化合物

生成物 1

HCID 22097020N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)-N-(2-[methylaminocarbonyl]aminoethyl) methanesulphonamide収率 91%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Methylisocyanate (8.2 μl, 8.0 mg, 0.14 mmol) was added to a solution of N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)-N-(2-aminoethyl)-methanesulphonamide (from Preparation 27, 50 mg, 0.127 mmol) in dichloromethane (2 ml) at room temperature under nitrogen. After 30 minutes the mixture was concentrated under reduced pressure. The residue was dissolved in ethyl acetate and concentrated under reduced pressure to give N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)-N-(2-[methylaminocarbonyl]aminoethyl) methanesulphonamide as a pale yellow foam (52 mg, 91%).

後処理

  1. concentrationAfter 30 minutes the mixture was concentrated under reduced pressure
  2. dissolutionThe residue was dissolved in ethyl acetate
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-790b989a9e4544fb98a0035504d2b89e
出典データセット
uspto-grants-1998_12
特許番号
US05852016

反応ノート

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