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Indole-3-Carboxylic Acid → (1-Benzyl-4-piperidyl)methyl indole-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Indole-3-Carboxylic Acid | HCID 69867 | — |
| 反応物 | (1-Benzylpiperidin-4-yl)methanol | HCID 736802 | — |
| 生成物 | (1-Benzyl-4-piperidyl)methyl indole-3-carboxylate | HCID 19599412 | 88% |
反応手順
Indole-3-carboxylic acid was converted to its acid chloride and then reacted with 1-benzyl-4-piperidinemethanol (D7) using the method given in Example 1a. The resulting orange oil was chromatographed on silica gel eluting with chloroform/ethanol (9:1) to afford (1-benzyl-4-piperidyl)methyl indole-3-carboxylate as a yellow oil (88%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05852014 |
| 出典データセット | uspto-grants-1998_12 |
| ORD ID | ord-f803b1fddf174cc78f067da1fe213c9a |
| 出典メモ | uspto-grants-1998_12 |