Triethylamine → HCID 178437738、化合物

HRID 1458648

反応式

HRID 1458648 の反応式
Cl[C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([CH2:12][CH3:13])[N:5]=[CH:4][N:3]=1.[CH3:14][Si:15]([CH3:24])([CH3:23])[C@@H:16]1[CH2:21][CH2:20][C@H:19]([NH2:22])[CH2:18][CH2:17]1.C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH2:12]([C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:22][C@H:19]2[CH2:18][CH2:17][C@@H:16]([Si:15]([CH3:24])([CH3:23])[CH3:14])[CH2:21][CH2:20]2)[C:7]=1[C:8]([O:10][CH3:11])=[O:9])[CH3:13]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 220974154-Chloro-6-ethyl-5-methoxycarbonylpyrimidineHCID 178504289HCID 178504289、化合物

生成物 1

HCID 178437738HCID 178437738、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

12.4 g (62.0 mmol) of 4-chloro-6-ethyl-5-methoxycarbonylpyrimidine, 11.1 g (62.0 mmol) of cis-4-trimethylsilylcyclohexylamine and 12.55 g (124 mmol) of triethylamine were heated in 30 ml of toluene at 90° C. for 3 hours. After complete reaction, the mixture was partitioned between dichloromethane and water to give, after further extraction with dichloromethane and column chromatography on silica gel, 17.76 g (85.4% of theory) of the cyclohexylaminopyrimidine as a pale brown oil, nD21 =1.5230.

後処理

  1. customAfter complete reaction
  2. customthe mixture was partitioned between dichloromethane and water
  3. customto give
  4. extractionafter further extraction with dichloromethane and column chromatography on silica gel, 17.76 g (85.4% of theory) of the cyclohexylaminopyrimidine as a pale brown oil

出典と根拠

ORDレコード
ord-e802fb558d72422cba99b4c191fecb8e
出典データセット
uspto-grants-1998_12
特許番号
US05852023

関連ノート

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