Hydrogen iodide → HCID 178445670、化合物
反応式
[C:1]([C@@H:5]1[CH2:10][CH2:9][C@H:8]([NH:11][C:12]2[CH:17]=[C:16](Cl)[N:15]=[CH:14][N:13]=2)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[IH:19]>>[C:1]([C@@H:5]1[CH2:10][CH2:9][C@H:8]([NH:11][C:12]2[CH:17]=[C:16]([I:19])[N:15]=[CH:14][N:13]=2)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2]参加物
3
実験手順
2.0 g (7.5 mmol) of 4-(cis-4-tert-butylcyclohexylamino)-6-chloropyrimidine were heated at reflux for 5 hours in 20 ml of aqueous hydroiodic acid (57% strength). After cooling the mixture was filtered with suction, the solid was suspended in water and the suspension was rendered basic using ammonia solution. It was extracted with dichloromethane and the organic phase was dried and concentrated, to leave 1.2 g (44.5% of theory) of colorless resin which gradually crystallized.
後処理
- temperatureAfter cooling the mixture
- filtrationwas filtered with suction
- extractionIt was extracted with dichloromethane
- customthe organic phase was dried
- concentrationconcentrated
- customto leave 1.2 g (44.5% of theory) of colorless resin which