Triethylamine → HCID 178470708、化合物

反応式

Cl[C:2]1[C:7]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[C:6]([CH3:13])[N:5]=[CH:4][N:3]=1.[C:14]([C@@H:18]1[CH2:23][CH2:22][C@H:21]([NH2:24])[CH2:20][CH2:19]1)([CH3:17])([CH3:16])[CH3:15].[CH2:25](N(CC)CC)C>O.C1(C)C=CC=CC=1>[C:14]([C@@H:18]1[CH2:19][CH2:20][C@H:21]([NH:24][C:2]2[C:7]([CH2:8][C:9]([O:11][CH2:12][CH3:25])=[O:10])=[C:6]([CH3:13])[N:5]=[CH:4][N:3]=2)[CH2:22][CH2:23]1)([CH3:17])([CH3:15])[CH3:16]

参加物

実験手順

15.2 g (71 mmol) of methyl (4-chloro-6-methylpyrimidin-5-yl)acetate, 11.0 g (71 mmol) of cis-4-tert-butylcyclohexylamine and 20.2 g (0.2 mol) of triethylamine were heated at 80° to 90° C. for 6 hours without solvent. After cooling, the mixture was taken up in water/toluene and the organic phase was dried and concentrated. In the chromatography on silica gel (petroleum ether/ethyl acetate 1:1, then ethyl acetate/methanol 9:1), 5.3 g of chloropyrimidine starting material were first of all retained and then 10.0 g (27.7% of theory) of product were obtained as a yellow solid.