Hydrochloric Acid → Benzoic acid, m-(bis(2-chloroethyl)amino)-
反応式
Cl.[Cl:2][CH2:3][CH2:4][N:5]([C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12]([O:14]C)=[O:13])[CH2:6][CH2:7][Cl:8]>O>[Cl:2][CH2:3][CH2:4][N:5]([C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12]([OH:14])=[O:13])[CH2:6][CH2:7][Cl:8]参加物
4
実験手順
Concentrated hydrochloric acid (40 ml) was added to 2.0 g (7.44 mmol) of methyl 3-[N,N-bis(2-chloroethyl)amino]benzoate, followed by stirring under heating for 3 hours over an oil bath which was controlled at 90° C. The reaction mixture was diluted with water. The resulting crystals were collected by filtration and then washed with 50% ethanol, whereby 1.95 g (7.44 mmol) of the title compound were obtained as white crystals (yield: quantitative).
後処理
- temperatureunder heating for 3 hours over an oil bath which
- customwas controlled at 90° C
- filtrationThe resulting crystals were collected by filtration
- washwashed with 50% ethanol
出典と根拠
- ORDレコード
- ord-8365445a8c204108bf4e48374bba2a97
- 出典データセット
- uspto-grants-1998_12
- 特許番号
- US05852011
反応ノート
読み込み中…