Diethyl Oxalate → 1-cyclohexyl-6-trifluoromethyl-2,3(1H,4H)-quinoxalinedione
反応式
[CH:1]1([NH:7][C:8]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:9]=2[NH2:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:19](OCC)(=[O:25])[C:20](OCC)=[O:21]>>[CH:1]1([N:7]2[C:8]3[C:9](=[CH:11][C:12]([C:15]([F:16])([F:17])[F:18])=[CH:13][CH:14]=3)[NH:10][C:20](=[O:21])[C:19]2=[O:25])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1参加物
3
実験手順
28 g (0.11 mol) of 2-cyclohexylamino-5-trifluoromethylaniline and 322 g (2.2 mol) of diethyl oxalate were refluxed for 2 hours. The reaction mixture was then concentrated, and the crude product was recrystallized from ethanol.
後処理
- concentrationThe reaction mixture was then concentrated
- customthe crude product was recrystallized from ethanol
出典と根拠
- ORDレコード
- ord-b4be6952f953497a8515621c70bbb5cc
- 出典データセット
- uspto-grants-1998_12
- 特許番号
- US05852017
反応ノート
読み込み中…