Imidazole → HCID 22097613、化合物

HRID 1458949ノート

反応式

HRID 1458949 の反応式
Br[CH2:2][CH2:3][CH2:4][C:5]([O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:6].[NH:15]1[CH:19]=[CH:18][N:17]=[CH:16]1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[N:15]1([CH2:2][CH2:3][CH2:4][C:5]([O:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:6])[CH:19]=[CH:18][N:17]=[CH:16]1

参加物

5

反応物 3

HCID 795ImidazoleHCID 11430Potassium CarbonateHCID 3832489Benzyl 4-bromobutanoate

生成物 1

HCID 22097613HCID 22097613、化合物収率 33%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of benzyl 4-bromobutyrate (23.7 g), imidazole (8.1 g), potassium carbonate (14.0 g) and acetone (400 ml) was stirred under reflux for 6 hours. After cooling the mixture to room temperature, the insoluble material was filtered off, and the filtrate was concentrated. The residual oil was subjected to column chromatography on silica gel. The fractions eluted with ethyl acetate/methanol (20/1, v/v) gave benzyl 4-(1-imidazolyl)butyrate (7.3 g, 33%) as an oil.

後処理

  1. temperatureunder reflux for 6 hours
  2. filtrationthe insoluble material was filtered off
  3. concentrationthe filtrate was concentrated
  4. washThe fractions eluted with ethyl acetate/methanol (20/1

出典と根拠

ORDレコード
ord-eab473ec92be457f91bef9293b8f053f
出典データセット
uspto-grants-1998_12
特許番号
US05852039

反応ノート

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