HCID 22097613、化合物 → Imidazole-1-butyric acid

HRID 1458950ノート

反応式

HRID 1458950 の反応式
[N:1]1([CH2:6][CH2:7][CH2:8][C:9]([O:11]CC2C=CC=CC=2)=[O:10])[CH:5]=[CH:4][N:3]=[CH:2]1>[C].[Pd].C(O)C>[N:1]1([CH2:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:4][N:3]=[CH:2]1

参加物

4

反応物 1

HCID 22097613HCID 22097613、化合物

生成物 1

HCID 3055390Imidazole-1-butyric acid収率 75%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

A mixture of benzyl 4-(1-imidazolyl)butyrate (7.4 g), palladium-carbon (5%)(1.0 g) and ethanol (400 ml) was subjected to catalytic hydrogenation at room temperature and 1 atm. The catalyst was filtered off, the filtrate was concentrated under reduced pressure, and the crystals were recrystallized from ethanol to give 4-(1-imidazolyl)butyric acid (3.4 g, 75%). Colorless prisms. mp. 125°-126° C.

後処理

  1. customwas subjected to catalytic hydrogenation at room temperature
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customthe crystals were recrystallized from ethanol

出典と根拠

ORDレコード
ord-6baa2d2489df46e79ff455de90459d12
出典データセット
uspto-grants-1998_12
特許番号
US05852039

反応ノート

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