p-Toluenesulfonic acid monohydrate → 2-benzyloxymethyl-propane-1,3-diol

HRID 1459162ノート

反応式

HRID 1459162 の反応式
[CH2:1]([O:8][CH2:9][CH:10]1[CH2:15][O:14]C(C)(C)[O:12][CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[CH2:1]([O:8][CH2:9][CH:10]([CH2:15][OH:14])[CH2:11][OH:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 232952655-((Benzyloxy)methyl)-2,2-dimethyl-1,3-dioxane

生成物 1

HCID 102417822-benzyloxymethyl-propane-1,3-diol収率 80%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 5-benzyloxymethyl-2,2-dimethyl-1,3-dioxane (3.40 g, 14.4 mmol) and a few crystals of p-toluenesulfonic acid monohydrate in 100 mL of methanol was stirred at room temperature for 20 h. The methanol was removed in vacuo and the residual oil purified by column chromatography on silica gel (ethyl acetate) to give 2.25 g (80%) of 2-benzyloxymethyl-1,3-propanediol as a colorless, clear liquid.

後処理

  1. customThe methanol was removed in vacuo
  2. customthe residual oil purified by column chromatography on silica gel (ethyl acetate)

出典と根拠

ORDレコード
ord-a1b0a27d31e5423ca1d9533fd44f2c34
出典データセット
uspto-grants-1998_12
特許番号
US05854228

反応ノート

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