Carbon tetrabromide → Ethyl 2-[4-(bromomethyl)phenoxy]acetate

HRID 1459434ノート

反応式

HRID 1459434 の反応式
O[CH2:2][C:3]1[CH:15]=[CH:14][C:6]([O:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:5][CH:4]=1.C(Br)(Br)(Br)[Br:17].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C(Cl)Cl>[Br:17][CH2:2][C:3]1[CH:15]=[CH:14][C:6]([O:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 11413157Acetic acid, [4-(hydroxymethyl)phenoxy]-, ethyl ester

生成物 1

HCID 12870369Ethyl 2-[4-(bromomethyl)phenoxy]acetate収率 74.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a 1 L round bottomed flask with a stirring bar, addition funnel and an argon inlet was added ethyl 2-(4-hydroxymethylphenoxy)acetate 35-4 (7.47 g, 35.53 mmol), CBr4 (13.26 g, 39.97 mmol) and dry CH2Cl2 (300 mL). This solution was cooled in an ice bath and and a solution of triphenyl phosphine (10.48 g, 39.97 mmol) in CH2Cl2 (100 mL) was added dropwise over 1 h. The ice bath was allowed to expire and and the mixture was stirred at ambient temperature 18 h. The solvent was removed in vacuo and the residue was chromatographed directly on 200 g of silica gel useing 15% EtOAc-hexane as eluant. There was obtained ethyl 2-(4-bromomethylphenoxy)acetate 35-5 (7.2 g, 74%) as a low melting solid, mp.: 44°-45° C. 1H NMR (CDCl3): δ 1.29 (t, J=7 Hz, 3H), 4.26 (q, J=7 Hz, 2H), 4.48 (s, 2H), 4.61 (s, 2H), 6.86 (d, J=9 Hz, 2H), 7.32 (d, J=9HZ, 2H).

後処理

  1. additionTo a 1 L round bottomed flask with a stirring bar, addition funnel and an argon inlet
  2. temperatureThis solution was cooled in an ice bath
  3. customThe solvent was removed in vacuo
  4. customthe residue was chromatographed directly on 200 g of silica gel useing 15% EtOAc-hexane as eluant

出典と根拠

ORDレコード
ord-0e09a5f283984d4ab65d8843efe6c82e
出典データセット
uspto-grants-1998_12
特許番号
US05854245

反応ノート

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