4-Chlorobenzylamine → Nicotinic acid, 2-(p-chlorobenzylamino)-

HRID 1459449ノート

反応式

HRID 1459449 の反応式
Cl[C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Cl:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][NH2:17])=[CH:14][CH:13]=1>>[Cl:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][NH:17][C:2]2[N:10]=[CH:9][CH:8]=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])=[CH:14][CH:13]=1

参加物

3

反応物 2

HCID 660364-ChlorobenzylamineHCID 762582-Chloronicotinic acid

生成物 1

HCID 214597Nicotinic acid, 2-(p-chlorobenzylamino)-

反応条件

温度
120 °C

実験手順

A mixture of 2-chloronicotinic acid (30.0 g) and 4-chlorobenzylamine (45 ml) was heated at 120° C. for 3.5 hours. The mixture was cooled to ambient temperature and the solid obtained was washed with water and collected by filtration. The solid was boiled in methanol and filtered to give 2-(4-chlorobenzylamino)-nicotinic acid, m.p. 240°-242° C.

後処理

  1. temperatureThe mixture was cooled to ambient temperature
  2. customthe solid obtained
  3. washwas washed with water
  4. filtrationcollected by filtration
  5. filtrationfiltered

出典と根拠

ORDレコード
ord-ec2ac6cea6f04b0d807284ac0a9c537e
出典データセット
uspto-grants-1998_12
特許番号
US05854257

反応ノート

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