Water → HCID 19981885、化合物

反応式

[C:1]([O-:4])(=[S:3])[CH3:2].[K+].Cl[CH:7]([C:13]1[CH:18]=[CH:17][C:16]([CH3:19])=[C:15]([CH3:20])[CH:14]=1)[C:8]([O:10][CH2:11][CH3:12])=[O:9].O>CN(C=O)C>[C:1]([S:3][CH:7]([C:13]1[CH:18]=[CH:17][C:16]([CH3:19])=[C:15]([CH3:20])[CH:14]=1)[C:8]([O:10][CH2:11][CH3:12])=[O:9])(=[O:4])[CH3:2]

参加物

実験手順

Potassium thioacetate (CH3COSK, 8.31 g) was added in small portions to a solution of ethyl 2-chloro-2-(3,4-dimethylphenyl)acetate (15 g) in DMF (80 ml). The mixture was stirred at room temperature for 2 hours, at the end of which time it was poured into water and extracted with ethyl acetate. The ethyl acetate layer was washed with water, dried (MgSO4) and the solvent was distilled off to give ethyl 2-acetylthio-2-(3,4-dimethylphenyl)acetate (16.5 g, 94%) as an oil.