Chlorodifluoromethane → HCID 13961960、化合物
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([S:9][CH3:10])[N:3]=1.Cl[CH:12]([F:14])[F:13]>>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH:12]([F:14])[F:13])[N:5]=[C:4]([S:9][CH3:10])[N:3]=1参加物
3
実験手順
On the other hand, in the latter process, 4-chloro-6-hydroxy-2-methylthiopyrimidine as the starting material is first reacted with monochlorodifluoromethane to obtain 4-chloro-6-difluoromethoxy-2-methylthiopyrimidine, then this product was reacted with sodium nitrite in dimethylformamide t obtain 4-hydroxy-6-difluoromethoxy-2-methylthiopyrimidine, which is further reacted with monochlorodifluoromethane in dioxane in the presence of potassium hydroxide to obtain desired 4,6-bis(difluoromethoxy)-2-methylthiopyrimidine at a yield of 50%. However, this process also involves long process steps and is very cumbersome, and as such, it is not suitable as an industrial process.
出典と根拠
- ORDレコード
- ord-6d835aa41cff4f3f8c5c4604176f94b2
- 出典データセット
- uspto-grants-1991_12
- 特許番号
- US05071982
反応ノート
読み込み中…