Potassium Carbonate → 1-Benzyloctahydropyrrolo[3,4-b]pyrrole
反応式
[CH2:1]([N:8]1[CH2:15][CH2:14][CH:13]2[CH:9]1[CH2:10][N:11](C(OCC)=O)[CH2:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+]>Cl>[CH2:1]([N:8]1[CH2:15][CH2:14][CH:13]2[CH:9]1[CH2:10][NH:11][CH2:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
55.6 g (0.2 mol) of ethyl 2-benzyl-2,7-diazabicyclo [3.3.0]octane-7-carboxylate are heated under reflux overnight with 300 ml of concentrated hydrochloric acid. The mixture is then rendered alkaline with potassium carbonate and extracted five times with 100 ml of chloroform each time, the extracts are dried over potassium carbonate and concentrated, and the residue is distilled.
後処理
- extractionextracted five times with 100 ml of chloroform each time
- dry with materialthe extracts are dried over potassium carbonate
- concentrationconcentrated
- distillationthe residue is distilled
出典と根拠
- ORDレコード
- ord-ecc56e2601df45bfba6fa7163b46d8dd
- 出典データセット
- uspto-grants-1991_12
- 特許番号
- US05071999
反応ノート
読み込み中…