HCID 19100959、化合物 → 5-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

HRID 1460774ノート

反応式

HRID 1460774 の反応式
[Cl:1][C:2]12[CH2:9][N:8](C(OCC)=O)[CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2>Cl>[Cl:1][C:2]12[CH2:9][NH:8][CH2:7][CH:6]1[N:5]([CH3:15])[CH:4]([CH3:16])[CH2:3]2

参加物

3

反応物 1

HCID 19100959HCID 19100959、化合物

生成物 1

HCID 191009535-Chloro-2,3-dimethyl-2,7-diazabicyclo[3.3.0]octane

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

7.6 g (30.8 mmol) of ethyl 5-chloro-2,3-dimethyl -2,7-diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux overnight with 30 ml of concentrated hydrochloric acid. The mixture is concentrated, the residue is taken up in 30 ml of water, and the mixture is rendered alkaline with potassium carbonate, extracted five times with 50 ml of chloroform each time, dried over potassium carbonate and concentrated, and the residue is distilled.

後処理

  1. concentrationThe mixture is concentrated
  2. extractionextracted five times with 50 ml of chloroform each time
  3. dry with materialdried over potassium carbonate
  4. concentrationconcentrated
  5. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-d7d525b1bf1644beb95e52e2b90c38a9
出典データセット
uspto-grants-1991_12
特許番号
US05071999

反応ノート

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