HCID 19100973、化合物 → HCID 19100943、化合物

HRID 1460798ノート

反応式

HRID 1460798 の反応式
[F:1][CH2:2][C:3]12[CH2:10][N:9](C(OCC)=O)[CH2:8][CH:7]1[N:6]([CH3:16])[CH2:5][CH2:4]2>Cl>[F:1][CH2:2][C:3]12[CH2:10][NH:9][CH2:8][CH:7]1[N:6]([CH3:16])[CH2:5][CH2:4]2

参加物

3

反応物 1

HCID 19100973HCID 19100973、化合物

生成物 1

HCID 19100943HCID 19100943、化合物

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

7.1 g (26 mmol) of ethyl 5-fluoromethyl-2-methyl -2,7-diazabicyclo[3.3.0]octane-7-carboxylate are heated under reflux overnight in 100 ml of concentrated hydrochloric acid. The mixture is concentrated, the residue is taken up in 20 ml of water, the mixture is rendered alkaline with potassium carbonate and extracted ten times using 50 ml of chloroform each time, the extracts are dried over potassium carbonate and concentrated, and the residue is distilled.

後処理

  1. concentrationThe mixture is concentrated
  2. extractionextracted ten times
  3. dry with materialthe extracts are dried over potassium carbonate
  4. concentrationconcentrated
  5. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-8c248f55d9ea445285a4869bd925270d
出典データセット
uspto-grants-1991_12
特許番号
US05071999

反応ノート

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