Hydrochloric Acid → 6-(Dimethylamino)-4,4-diphenylheptanoic acid

HRID 1461148ノート

反応式

HRID 1461148 の反応式
[CH3:1][N:2]([CH3:25])[CH:3]([CH3:24])[CH2:4][C:5]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH2:6][CH2:7][C:8]([O:10]C)=[O:9].C(=O)([O-])[O-].[K+].[K+].CO.Cl>O>[CH3:25][N:2]([CH3:1])[CH:3]([CH3:24])[CH2:4][C:5]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[CH2:6][CH2:7][C:8]([OH:10])=[O:9]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 11430Potassium CarbonateHCID 19981498Methyl 6-dimethylamino-4,4-diphenyl-heptanoate

生成物 1

HCID 2194886-(Dimethylamino)-4,4-diphenylheptanoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A mixture of methyl 6-dimethylamino-4,4-diphenyl-heptanoate (obtained above), potassium carbonate (500 mg), methanol (5 ml) and water (1 ml) was stirred at room temperature for 24 hours. The reaction mixture was diluted with water, acidified with 1N HCl to pH 1, and extracted with chloroform (3×). The combined extracts were washed with water and brine (once each). After drying over magnesium sulfate, the solution was rotary evaporated to yield 40 mg of 6-dimethylamino-4,4-diphenyl-heptanoic acid.

後処理

  1. extractionextracted with chloroform (3×)
  2. washThe combined extracts were washed with water and brine (once each)
  3. dry with materialAfter drying over magnesium sulfate
  4. customthe solution was rotary evaporated

出典と根拠

ORDレコード
ord-5c2dd9e0e8e5416e9c0fdbd760508a75
出典データセット
uspto-grants-1991_12
特許番号
US05073629

反応ノート

読み込み中…